Researcher in Immunotherapy of cancer

Oslo universitetssykehus Se alle jobber

Oslo
Kontrakt
Fulltid

9 dager siden

Project description:Chimeric Antigen Receptor (CAR) therapies have demonstrated remarkable clinical efficacy in otherwise fatal cancers; however, their therapeutic success has so far been limited to a narrow range of tumour types. K101CAR, which targets the MUC16 antigen, represents a promising strategy for the treatment of pancreatic cancer.The aim of this project is to enhance the expression and performance of K101CAR using a fourth-generation CAR design. By implementing a virus-free transfection system, the project seeks to generate a product of superior quality, improved safety, and greater translational potential.Qualifications:The candidate must hold a PhD degree in a relevant scientific field and already have postdoctoral experience in immunology or immunotherapy.
Knowledge and practical experience in all of the following domains are mandatory and must be documented:

Immune cell culture (PBMC isolation, primary T-cell manipulation, and functional assays)
Immunological methods (flow cytometry, ELISA)
Animal experimentation (FELASA-C or equivalent certification)

Experience in one or more of the following areas will be considered an advantage:

Molecular biology (cloning, RNA isolation, qPCR, retro- or lentiviral manipulation)
Cell biology: spheroid or organoid culture, or organ-on-a-chip systems
CRISPR/Cas9 genome editing
Immunotherapy: vaccine development, BiTEs, immune receptors (TCR, CAR, or others)
Advanced microscopy (confocal) or live-cell imaging

The candidate should be hard-working, independent, and ambitious. We seek someone mature and responsible, capable of driving the project at the bench, organizing meetings with partners in 4KAPAI, and disseminating results.
We offer a dynamic and modern research environment equipped with state-of-the-art instruments and direct access to hospital core facilities. We support personal development and encourage training in relevant areas.The application (in English) must include: * Motivation letter (½ page, online): a brief explanation of why we should hire you, what you will bring to the lab, and your ambitions.

List (attachment-1): detailing the mandatory techniques listed above, including the lab where each was performed and any related publications. Additional relevant skills may also be included.
CV (use the online form) with all relevant information
List (attachment-2): publications/patents (title, authors, journal) with a brief description of your contribution to your top five.
Official copies of educational certificates (attachment-3) including grades.

Please respect the requested document lengths and do not use AI. Applications exceeding page limits, including unrequested documents, or containing AI-generated material will be disqualified.Address: Ullernchausseen 64/66, 0379 Oslo, NorwayContactsSebastien Philippe WälchliGroup leaderEmail: sebastw@ous-hf.noElse Marit InderbergUnit leaderEmail: elsin@ous-hf.noAbout the employerOslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia's largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel.

Oslo universitetssykehus

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