Postdoc fellowship

Oslo universitetssykehus

  • Oslo
  • Kontrakt
  • Fulltid
  • 18 dager siden
Project descriptionChimeric Antigen Receptor (CAR) molecules have shown outstanding therapeutic effects for the treatment of otherwise fatal cancers; however, clinical benefits have so far only been observed in a few tumour types. The present project aims at delivering potent CAR molecules with safer profile for clinical use in cancer.
The focus lies on (but is not restricted to) treatment of AML, B cell malignancies and solid tumours with peritoneal metastases. The current project is based on improvement of molecules that were recently published (Casey et al. 2023, Caulier et al. 2024, Abrantes & Forcados et al. 2025-accepted).However, it also includes the identification, design and testing of new constructs.QualificationsThe candidates must hold a PhD degree in Biology or Biochemistry. Other corresponding education in science (chemistry, physics, medicine, pharmacy, etc.) will be evaluated.Knowledge and practical experience in all the following domains are mandatory and should be documented:
- Immune cell culture (PBMC isolation, primary T-cell manipulation and functional assays)
- Immunological methods (flowcytometry, ELISA)
- Animal experiment (FELASA-C or equivalent)
Experience in one or more of the following areas will be considered as an advantage:
- Molecular biology (cloning, RNA isolation, qPCR, retro- or lentivirus manipulation)
- Cell biology: spheroid, organoid culture or organ on a chip
- Protein expression and purification (bacteria or mammalian cells)
- Immunotherapy: vaccine development, BiTE, immune Receptor work (TCR, CAR, or others)
- Advanced microscopy (confocal) or live cell imagingWe are looking for a motivated, hard-working and ambitious candidate, who can independently plan and perform experiments, write publications as well as applications and enjoys supervising students. Our team members work on different but related projects, therefore the candidate will have to share and collaborate, as well as participate in common responsibilities. We are a motivated, open and ambitious team which offers a dynamic and modern and well-equipped environment as well as direct access to the hospital core facilities. Furthermore, we support personal development and training in relevant areas.The application (in English) must include:
  • Motivation letter (1 page maximum) containing a short description of why you want to join us, how you will contribute to the team and your previous lab experience including the required above-listed mandatory techniques; Other relevant skills can also be included in addition to these
  • CV (1 page maximum) which should summarize education and previous positions. It should also include a list of laboratory techniques mastered, prizes, grants, awards and all relevant information about your skills
  • List of publications (2 pages maximum) with a short description of your contribution (patents as well as papers in preparation or submitted can be included)
Official copies of educational certificates (University levels) with gradesPlease respect the document length and do not use AI: exceeding document page number, addition of unrequested documents and AI-generated documents will lead to disqualification.Address: Ullernchausseen 64, 0379 Oslo, NorwayContactsSebastien Philippe WälchliGroup leaderEmail: sebastw@ous-hf.noAbout the employerOslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia's largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel.

Oslo universitetssykehus